Chiral LC Applications

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• Chiral Application Handbook

• Atropine on micro CHIRAL-AGP with MS and UV Detection

• Automated on-line extraction from cell cultures using BioTrap 500 MS

• Chiral bioanalysis of an ecstasy compound and metabolites on CHIRAL-CBH

• Chiral chromatography, drug-plasma protein binding and on-line/off-line sample preparation

• Chiral LC-MS: Amlodipine in human plasma on CHIRAL-AGP
• Chiral LC-MS: Bioanalysis of ketamine and norketamine on CHIRAL-AGP

• Simple routine method for warfarin enantiomers in plasma on CHIRAL-AGP

• Enantiospecific separation of mephenytoin and metabolites on CHIRAL-AGP MS/MS detection

• CHIRAL-CBH - an excellent choice for the separation of synephrine enantiomers. Comparison of three chiral columns

• Fast separations on short CHIRAL-CBH columns

• Bioanalysis of cetirizine enantiomers on CHIRAL-AGP with LC/MS/MS detection

• Recently developed chiral methods
• CHIRAL-AGP excellent choice for MS/MS detection - No matrix effects or ionization suppression

• Chromatography better than ultrafiltration and dialysis for drugprotein binding studies

• Fast Method Development for LC/MS (CHIRAL-AGP)
• Determination of enantiomeric purity
• The Magic Tool for Method Development

• Increase sensitivity with 3 mm ID columns

• Fast screening on CHIRAL-AGP, CHIRAL-CBH and CHIRAL-HSA
• Chiral separation of multifunctional complex drug compounds

• LC/MS methods on CHIRAL-AGP (examples from published literature)

• Validated protein binding method used for more than 4000 drug compounds

• Method Development for LC/MS detection
• How to choose a chiral column
• Using CHIRAL-AGP and CHIRAL-CBH for LC/MS

• Examples of complex chiral separations on CHIRAL-AGP and CHIRAL-CBH

• Columns for drug-protein binding studies
• Columns for drug-protein binding studies 2
• CHIRAL-AGP - a robust chiral column
• Amphetamine and Citalopram
• The BioTrap and RePeat Extraction Process
• The secret behind CHIRAL-AGP and pH
• Very simple method development
• Magic additives
• Column mix
• Chiral sample screening
• CHIRAL-AGP method optimization for LC/MS

• Some practical advices when using the CHIRALAGP, CHIRAL-CBH or CHIRAL-HSA columns

• Strategies for bioanalytical work on the CHIRAL-AGP column

• Increasing request for methods for the resolution of amino acid derivatives

• BioTrap 500 MS - a new way to fast bioanalysis

• CHIRAL-AGP, the chiral column with the broadest applicability

• Need to separate aminoalcohol enantiomers?

• Separation of the enantiomers of methadone and its metabolite EDDP using CHIRAL-AGP and MS-detection

• A robust and reliable isocratic method for the separation of the separation of the enantiomers of methadone and its metabolite EDDP using CHIRAL-AGP

• CHIRAL-CBH - A unique column for resolution of a wide variety of drugs and endogenous compounds

• Chiral LC/MS: Method development and mobile phases

• Chiral LC/MS: Verapamil and norverapamil on CHIRAL-AGP. UV-method converted to MS-Method

• Combine CHIRAL-AGP and CHIRAL-CBH for improved selectivity and resolution

• Agilent Ultron ES-OVM Chiral Column - A Bonded Ovomucoid Protein Column for Direct HPLC Separation of Chiral Compounds